Search results for " HDL; Cholesterol"

showing 5 items of 5 documents

A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency

2015

BackgroundLysosomal acid lipase is an essential lipid-metabolizing enzyme that breaks down endocytosed lipid particles and regulates lipid metabolism. We conducted a phase 3 trial of enzyme-replacement therapy in children and adults with lysosomal acid lipase deficiency, an underappreciated cause of cirrhosis and severe dyslipidemia. MethodsIn this multicenter, randomized, double-blind, placebo-controlled study involving 66 patients, we evaluated the safety and effectiveness of enzyme-replacement therapy with sebelipase alfa (administered intravenously at a dose of 1 mg per kilogram of body weight every other week); the placebo-controlled phase of the study was 20 weeks long and was followe…

AdultMalemedicine.medical_specialtyCirrhosisAdolescentHDLBiopsy[SDV]Life Sciences [q-bio]Lysosomal acid lipase deficiencyGastroenterologyLDLlaw.inventionYoung Adultchemistry.chemical_compoundDouble-Blind MethodRandomized controlled triallawInternal medicinemedicineHumansAdolescent; Adult; Aged; Alanine Transaminase; Biopsy; Child; Child Preschool; Cholesterol HDL; Cholesterol LDL; Double-Blind Method; Dyslipidemias; Female; Humans; Liver; Male; Middle Aged; Sterol Esterase; Wolman Disease; Young AdultChildPreschoolComputingMilieux_MISCELLANEOUSAgedDyslipidemiasbiologyCholesterolbusiness.industryWolman DiseaseAlanine TransaminaseLipid metabolismGeneral MedicineMiddle AgedSterol Esterasemedicine.disease3. Good healthCholesterolEndocrinologyLiverSebelipase alfachemistryAlanine transaminasebiology.proteinFemalebusinessDyslipidemia
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Serum magnesium and lipids: More clarity is needed

2007

Adultmedicine.medical_specialtyMagnetic Resonance SpectroscopyDiabetes; Lipids; Magnesium; Obesitychemistry.chemical_elementDiabeteInternal medicineDiabetes mellitusHumansMedicineMagnesiumObesityLdl cholesterolbusiness.industryMagnesiumCholesterol HDLDiabetesCholesterol hdlCholesterol LDLLipidmedicine.diseaseLipidsObesityEndocrinologyDiabetes Mellitus Type 2chemistryDiabetes; Lipids; Magnesium; Obesity; Adult; Cholesterol HDL; Cholesterol LDL; Diabetes Mellitus Type 2; Humans; Magnesium; Magnetic Resonance Spectroscopy; Cardiology and Cardiovascular MedicineCardiology and Cardiovascular MedicinebusinessHuman
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Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes—…

2015

Purpose: The optimal macronutrient composition of the diet for the management of type 2 diabetes is debated, particularly with regard to the ideal proportion of fat and carbohydrates. The aim of the study was to explore the association of different proportions of fat and carbohydrates of the diet—within the ranges recommended by different guidelines—with metabolic risk factors. Methods: We studied 1785 people with type 2 diabetes, aged 50–75, enrolled in the TOSCA.IT Study. Dietary habits were assessed using a validated food-frequency questionnaire (EPIC). Anthropometry, fasting lipids, HbA1c and C-reactive protein (CRP) were measured. Results: Increasing fat intake from <25 to ≥35 % is …

Blood GlucoseDietary FiberMale0301 basic medicineGlycated Hemoglobin AGlucose controlMedicine (miscellaneous)Type 2 diabetesSettore MED/13 - Endocrinologia0302 clinical medicineRisk FactorsSurveys and QuestionnairesDietary fatfat plsam lipids low-grade inflammationNutritional guidelinesNutrition and DieteticsbiologyType 2 diabetesMiddle AgedHDL-cholesterolCholesterolC-Reactive ProteinCarbohydrates diet fat Glucose control HDL-cholesterol Nutritional guidelines Triglycerides Type 2 diabetesCarbohydrates; Diet; Fat; Glucose control; HDL-cholesterol; Nutritional guidelines; Triglycerides; Type 2 diabetesFemaleDietary ProteinsType 2Dietary Carbohydratesmedicine.medical_specialtyHDLCarbohydrates030209 endocrinology & metabolismLDL03 medical and health sciencesInternal medicineGlucose controlPlasma lipidsDiabetes MellitusDietary CarbohydratesmedicineHumansIn patientCarbohydrates; Diet; Fat; Glucose control; HDL-cholesterol; Nutritional guidelines; Triglycerides; Type 2 diabetes; Medicine (miscellaneous); Nutrition and DieteticsTriglyceridesAgedGlycated HemoglobinInflammation030109 nutrition & dieteticsbusiness.industryCholesterol HDLC-reactive proteinCholesterol LDLAnthropometrymedicine.diseaseDietary FatsDietEndocrinologyDiabetes Mellitus Type 2Fatbiology.proteinDiet · Carbohydrates · Fat · Glucose control · HDL-cholesterol · Triglycerides · Type 2 diabetes · Nutritional guidelinesCarbohydrates; Diet; Fat; Glucose control; HDL-cholesterol; Nutritional guidelines; Triglycerides; Type 2 diabetes; Aged; Blood Glucose; C-Reactive Protein; Cholesterol HDL; Cholesterol LDL; Diabetes Mellitus Type 2; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Energy Intake; Female; Glycated Hemoglobin A; Humans; Inflammation; Male; Middle Aged; Risk Factors; Surveys and Questionnaires; TriglyceridesEnergy IntakebusinessEuropean Journal of Nutrition
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Repositioning of the global epicentre of non-optimal cholesterol

2020

Publisher's version (útgefin grein)

MaleMyocardial Ischemia/bloodBLOOD-PRESSUREtriglicéridos0302 clinical medicineCardiovascular diseases ; Risk factorsHDL cholesterol80 and overCARDIOVASCULAR RISK-FACTORSPublic health surveillance//purl.org/pe-repo/ocde/ford#3.02.04 [https]BlóðrásarsjúkdómarSocioeconomicsmediana edadComputingMilieux_MISCELLANEOUSPOPULATIONHypercholesterolemia/bloodAged 80 and overCholesterol HDL/bloodancianoeducation.field_of_studyKólesterólriskitekijätadulto3. Good healthadulto jovenTriglycerides/bloodCardiovascular diseasesGeographyCholesterolManchester Institute for Collaborative Research on AgeingCholesterol LDL/bloodDENSITY-LIPOPROTEIN CHOLESTEROLEndokrinologi och diabetesNCD Risk Factor Collaboration (NCD-RisC)Science & Technology - Other Topics//purl.org/becyt/ford/3 [https]Westernteorema de Bayesmedicine.medical_specialtyResearchInstitutes_Networks_Beacons/MICRAHDLMedicinaHypercholesterolemiahipercolesterolemiaNursingHEART-DISEASEEndocrinology and DiabetesHigh blood cholesterol.HDL-kolesteroliArticleLDLravintoHealth risk assessment03 medical and health sciences//purl.org/becyt/ford/3.3 [https]SDG 3 - Good Health and Well-beingBlood cholesterolHumanseducationSERUM-CHOLESTEROLVLAGAgedScience & TechnologyCholesterolPublic healthOmvårdnadHuman healthVDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710Bayes TheoremATHEROSCLEROSIS SOCIETYRisk factorschemistryLipid-lowering medicationsFaculdade de Ciências SociaisEast and southeast Asiaalueelliset erotInternationalityNutrition and Disease[SDV]Life Sciences [q-bio]kolesterolihumanosMyocardial IschemiaMedizinadolescenteNon-HDL cholesterolBlood lipids030204 cardiovascular system & hematologyisquemia miocárdicachemistry.chemical_compoundCholesterol epidemiologyMEDICATION USEVoeding en ZiekteMedicine and Health SciencesAdolescent; Adult; Aged; Aged 80 and over; Bayes Theorem; Cholesterol HDL; Cholesterol LDL; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Myocardial Ischemia; Stroke; Triglycerides; Young Adult; Internationality030212 general & internal medicine2. Zero hungerMultidisciplinaryMortality rateRepositioningStroke/blood1. No povertyPublic Health Global Health Social Medicine and EpidemiologycolesterolMiddle AgedVDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 7103142 Public health care science environmental and occupational healthPeer reviewStrokeMultidisciplinary SciencesTrend analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalelipids (amino acids peptides and proteins)LIPIDSAdultAdolescentGeneral Science & TechnologyPopulationepicentre20-YEAR TRENDSYoung AdultmedicineLife Scienceddc:610accidente cerebrovascularDisease burdenTriglyceridesNutritionHigh density lipoproteinsnon-optimal cholesterolCholesterol HDLinternacionalidadCholesterol LDLTreatmentFolkhälsovetenskap global hälsa socialmedicin och epidemiologi
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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analy…

2020

Artículo con numerosos autores. Sólo quedan reflejados el primero, los pertenecientes a la UAM y el colectivo

Malegupo de ascendencia continental asiáticaSettore MED/09 - Medicina InternaTotal Cholesterol ; Ldl Cholesterol ; Hdl Cholesterol ; Blood Lipids ; Multi-country StudyEpidemiologykolesterolihumanosBlood lipidsBLOOD-PRESSURE030204 cardiovascular system & hematologytriglicéridoschemistry.chemical_compound0302 clinical medicineHigh-density lipoproteinHDL cholesterolEpidemiologyMedicine and Health SciencesCARDIOVASCULAR RISK-FACTORSMedicine030212 general & internal medicinemediana edadlípidosPublic Environmental & Occupational Health2. Zero hungerancianoeducation.field_of_studyAge FactorsPublic Health Global Health Social Medicine and EpidemiologyGeneral MedicineMiddle Agedcolesteroladultokansainvälinen vertailuLipids3142 Public health care science environmental and occupational health3. Good healthEuropeCholesterolPopulation SurveillanceLDL cholesterolSERUM-LIPIDSFemalelipids (amino acids peptides and proteins)Life Sciences & BiomedicineAdultAsian Continental Ancestry GroupCanadaHDL cholesterol; LDL cholesterol; Total cholesterol; blood lipids; multi-country studymedicine.medical_specialtyAsiaMedicinaEuropean Continental Ancestry GroupPopulationNursingHDL-kolesteroliWhite PeopleDIETARY-FAT03 medical and health sciencesSex FactorsAsian Peoplekansanterveysvigilancia de la poblaciónTotal cholesterolHumansCORONARY-HEART-DISEASEmulti-country studyddc:610LDL-kolesteroliTotal cholesteroleducationTriglyceridesMETAANALYSISAgedINDIVIDUAL DATAScience & Technologyblood lipidsbusiness.industryCholesterolOmvårdnadblood lipidCholesterol HDLEcological studynutritional and metabolic diseasesCholesterol LDLUnited StatesFolkhälsovetenskap global hälsa socialmedicin och epidemiologiAdult; Age Factors; Aged; Asia; Asian Continental Ancestry Group; Canada; Cholesterol/blood; Cholesterol HDL; Cholesterol LDL; Europe; European Continental Ancestry Group; Female; Humans; Lipids/blood; Male; Middle Aged; Population Surveillance/methods; Sex Factors; Triglycerides/blood; United States; HDL cholesterol; LDL cholesterol; Total cholesterol; blood lipids; multi-country studychemistryWORLDWIDE TRENDSMulti-country study ; Total cholesterol ; HDL cholesterol ; LDL cholesterol ; Blood lipidsgrupo de ascendencia continental europeabusinessHIGH-DENSITY-LIPOPROTEIN[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyDemographyLipoprotein
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