Search results for "F.1.2"

Cádiz en Charcas: conjeturas e indicios

2012

Este es un artículo de historia constitucional. Se centra en la relación entre la Constitución española de 1812 y la Constitución boliviana de 1826. Su conclusión principal niega la idea de que, por el solo hecho de que ambas fueron cartas liberales contemporáneas entre sí escritas en la misma lengua, la primera Constitución haya influenciado en la segunda. Al contrario, toma a las semejanzas de redacción como un mero mecanismo de auxilio técnico, pero no por una fuente de influencia. Y, no las califica así, porque la influencia supone una relación de autoridad moralmente justificada, lo que, precisamente, estaba ausente entre el poder metropolitano y sus colonias. Una serie de documentos h…

A phase I study of nintedanib combined with cisplatin/gemcitabine as first-line therapy for advanced squamous non-small cell lung cancer (LUME-Lung 3)

2018

Abstract Background There are limited treatment options for squamous non-small cell lung cancer (sqNSCLC) and prognosis remains poor. The safety and pharmacokinetics (PK) of nintedanib, a triple angiokinase inhibitor, plus cisplatin/gemcitabine as first-line treatment for advanced sqNSCLC patients, were evaluated. Materials and methods A phase I, dose-escalation study administering drugs in a 21-day cycle: cisplatin (75 mg/m2, Day 1), gemcitabine (1250 mg/m2, Days 1 and 8) and nintedanib (Days 2–7, 9–21) were given for 4–6 cycles, followed by monotherapy until disease progression or adverse events (AEs). Two nintedanib doses were tested, 150 mg twice daily (bid) and 200 mg bid, to determine…

La pena de trabajos forzados en los códigos penales decimonónicos

2018

This paper is an study about the penalty of forced labor, inside the historical and legal framework in which took place the criminal law codification of 19th century (Criminal Codes of 1822, 1848 and 1870) and the departure from the Criminal Law of Ancient Regime

On Physical Problems that are Slightly More Difficult than QMA

2013

We study the complexity of computational problems from quantum physics. Typically, they are studied using the complexity class QMA (quantum counterpart of NP) but some natural computational problems appear to be slightly harder than QMA. We introduce new complexity classes consisting of problems that are solvable with a small number of queries to a QMA oracle and use these complexity classes to quantify the complexity of several natural computational problems (for example, the complexity of estimating the spectral gap of a Hamiltonian).

One-counter verifiers for decidable languages

2012

Condon and Lipton (FOCS 1989) showed that the class of languages having a space-bounded interactive proof system (IPS) is a proper subset of decidable languages, where the verifier is a probabilistic Turing machine. In this paper, we show that if we use architecturally restricted verifiers instead of restricting the working memory, i.e. replacing the working tape(s) with a single counter, we can define some IPS's for each decidable language. Such verifiers are called two-way probabilistic one-counter automata (2pca's). Then, we show that by adding a fixed-size quantum memory to a 2pca, called a two-way one-counter automaton with quantum and classical states (2qcca), the protocol can be spac…

BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer.

2013

Abstract: Introduction: Several new targeted agents with anti-angiogenic properties have been developed recently, including vandetanib, sunitinib, sorafenib, bevacizumab and others. Tumor development, progression, metastasis are strongly linked to angiogenesis. Targeted agents like bevacizumab, a monoclonal antibody which targets VEGF, have been fully developed in several solid tumors. These new agents strongly advocate that targeting angiogenesis is one of the best approaches for cancer therapy. Areas covered: Those agents that target additional pro-angiogenic intracellular signaling pathways beyond VEGF signaling have also the potential to contribute to anticancer therapies. The authors p…

Synthesis and antiproliferative activities of two new analogs of tetrazepinones

Based on the encouraging results, we report the multistep synthesis and the biologicalo results of two new analogs of tetrazepinones: the 3,5-dimethyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one and the 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one. Both compounds showed a pro-apoptotic activity against HL60 and K562 resistant cell lines. Flow cytometry studies carried out 0n K562 cells allowed to establish that the methyl derivative induces G0-G1, phase arrest followed by apoptosis, whereas the chloroethyl derivative is a not phase-specific agent.

La tradición clásica como referencia de vanguardia: la Antigüedad griega y romana en la obra del pintor Gregorio Prieto (1897-1992)

2019

This article analyses the impact of classical tradition on the artistic production of Gregorio Prieto (1897-1992), painter par excellence of the Generation of 1927. It will be discovered how this influence, far from becoming a conservative reference, would constitute an incentive for his entailment with the avant-garde, especially with surrealism. Although the classic trace is found with more intensity in the creations produced during his Roman years, between 1928 and 1929, when he also made important trips to Sicily and Greece, Greece and Rome would nevertheless continue to be constitutive of his aesthetic experience throughout his later and extensive career.

Topological properties of cellular automata on trees

2012

We prove that there do not exist positively expansive cellular automata defined on the full k-ary tree shift (for k>=2). Moreover, we investigate some topological properties of these automata and their relationships, namely permutivity, surjectivity, preinjectivity, right-closingness and openness.

The ambiguities of "granted constitutionalism" : a transatlantic debate (III)

2018

Our journey ends in Brazil. According to textbooks of constitutional history, this "periphery" country, recently independent, looked with envy at the European and North American constitutional novelties, not without trying to maintain its identity. Olhos na Europa, pés na América? Doubtless ; still it is necessary to measure the extent of this "Europe", admired in space as in time. The doctrine, criticizing the granted Constitution of 1824, qualified of nominal, had too long hid the reality, even the efficiency, of a constitutionalism in singular outlines, which involves both social and institutional engineering, thus not reducible to the modern constitutionalism. The political actors of Br…