Search results for "NSUN"
showing 10 items of 10 documents
Sedimentary environment, lithostratigraphy and dating of sediment sequences from Arctic lakes Revvatnet and Svartvatnet in Hornsund, Svalbard
2016
Abstract The sedimentary environment, sediment characteristics and age-depth models of sediment sequences from Arctic lakes Revvatnet and Svartvatnet, located near the Polish Polar Station in Hornsund, southern Svalbard (77°N), were studied with a view to establishing a basis for paleolimnological climate and environmental reconstructions. The results indicate that catchment-to-lake hydroclimatic processes probably affect the transportation, distribution and accumulation of sediments in different parts of lakes Revvatnet and Svartvatnet. Locations with continuous and essentially stable sedimentary environments were found in both lakes between water depths of 9 and 26 m. We used several diff…
Riflessioni a margine della didattica
2007
Il testo riassume l'esperienza didattica condotta dall'Autore nell'ambito del Laboratorio di Restauro dei Monumenti, da lui tenuto nell'a.a. 2005-06. Di questa ne sintetizza le linee guida, i contenuti e i risultati finali. Il testo è corredato da una selezione di elaborati grafici prodotti dagli studenti, da fotografie e da due brevi contributi dei docenti dei moduli afferenti al Laboratorio stesso.
Redistribution, selection, and trade
2017
Abstract This paper examines the distributional effects of international trade in a general equilibrium model with heterogeneous agents and a welfare state redistributing income. The redistribution scheme is financed by a progressive income tax and gives the same absolute transfer to all individuals. Ceteris paribus, international trade leads to an increase in income per capita but also to higher income inequality on two fronts. Inter-group inequality between managers and workers increases, and intra-group inequality within the group of managers goes up as well. We show that for a given tax rate, there is an endogenous increase in the size of the welfare state that works against the increas…
Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans
2021
Abstract Methylation of carbon‐5 of cytosines (m5C) is a post‐transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been studied, the impact of the global cytosine‐5 methylome on development, homeostasis and stress remains unknown. Here, using Caenorhabditis elegans, we generated the first organism devoid of m5C in RNA, demonstrating that this modification is non‐essential. Using this genetic tool, we determine the localisation and enzymatic specificity of m5C sites in the RNome in vivo. We find that NSUN‐4 acts as a dual rRNA and tRNA methyltransferase in C. elegans mitochondria. In agreement with leucine and proline bein…
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
2012
The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylate…
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown. By comparing gene expression data with global cytosine-5 RNA methylomes in patient fibroblasts and NSun2-deficient mice, we find that loss of cytosine-5 RNA methylation increases the angiogenin-mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5' tRNA-derived small RNA fragments. Accumulation of 5' tRNA fragments in the absence of NSun2 reduces protein translation rates and activates stress pathways leading to reduced cell siz…
"Oli kerrankin hauskaa mutta oppi samalla" : stationsundervisning på gymnasienivå
2015
Tämän maisterintutkielman tarkoituksena oli kartoittaa kahden ruotsinopettajan ja heidän ruotsin ryhmiensä suhtautumista laatimaani yhteistoiminnalliseen oppimateriaaliin ja työpistetyös-kentelyyn opetusmenetelmänä. Oppimateriaali koostui seitsemästä työpistetehtävästä, joita käy-tettiin kahden lukiolaisryhmän 45 minuutin ruotsin oppitunnilla. Yhteistoiminnallisen oppitunnin jälkeen selvitettiin kyselylomakkeella, miten opiskelijaryhmät suhtautuvat materiaaliin sekä haastateltiin heidän opettajiaan. Samalla kartoitettiin myös, miten opiskelijat ja opettajat yleensä ottaen suhtautuvat yhteistoiminnallisiin työtapoihin, joista esimerkkinä käytettiin työpistetyös-kentelyä. Tutkimusmateriaali k…
Returns To Education During And After The Economic Crisis: Evidence From Latvia 2006–2012
2017
We employ EU-SILC micro data for Latvia to study how returns to education changed during the economic crisis of 2008–2009 and afterwards. We found that returns to education increased significantly during the crisis and decreased slightly during the subsequent economic recovery. The counter-cyclical effect was evident in nearly all population groups. After the crisis, education became more associated than before with a longer working week and a higher employment probability. Furthermore, we show that returns to education in Latvia are generally higher in the capital city and its suburbs than outside the capital city region, as well as for citizens of Latvia than for resident non-citizens and…
Lärarstudenter som aktörer i interaktiv observation och handledning: En studie om digitala redskap i VFU-handledning på övningsskolor
2018
Source at https://doi.org/10.23865/hu.v8.1078. Licensed CC BY-NC-ND 4.0. Syftet med denna artikel är att bidra med kunskap om hur digitala redskap kan påverka lärarstudenters deltagande i handledningsprocessen. Trots att lärarstudenter och handledare ofta befinner sig i digitala klassrumsmiljöer används digitala redskap endast i begränsad omfattning under handledningsprocessen. Med utgångspunkt i Wengers teori om lärande i en praktikgemenskap har lärarstudenter och handledare arbetat med stöd av digitala observationsunderlag. Processen har studerats på fyra övningsskolor. Information om studenternas erfarenheter av handledningen har samlats in via enkäter och fokusgruppsamtal. Resultatet vi…